Abstract: The east route of the South-to-North Water Transfer Project is characterized by long transmission lines, multiple influencing factors, and complex working conditions. Analyzing the hydraulic characteristics of the river is fundamental to ensuring the safe and efficient operation of large cascade pumping stations. This paper focuses on the river section from Sihong Station to Suining Station and establishes a one-dimensional hydrodynamic model of the river channel based on MIKE11. The hydraulic characteristics of the river channel are analyzed from three perspectives: reservoir storage, hydraulic loss, and hydraulic response characteristics. Results indicate that the model has an average water level error of 0.044 m. This paper analyzes the variation characteristics of river hydraulic loss and proposes suggestions for reducing hydraulic loss and increasing water transfer efficiency. It also reveals the relationship between water level and the flow-storage capacity curve. Results indicate that the rate of upstream water inflow can be managed by adjusting the water level and allocating reservoir storage reasonably, offering insights for the safe operation of pumping stations during switchovers and emergencies.