Abstract: On the basis of preliminary numerical simulation studies, movable and immovable bed experiments of the Yangtze estuary have been taken as the alternative schemes, the recommended schemes and the preliminary design schemes. Waterway regulation effects, beach protection and the influences of the regulation works upon river regime, flood control, and ambient environment are analyzed and compared from aspects of hydrodynamic changes and riverbed scour-and-fill process. The research results show that the requirements of 500 m ×12. 5 m deep waterway can be met through a little dredging operation, and that the preliminary design schemes are relatively reasonable. The related research achievements have been applied to the waterway regulation engineering design and the decision-making of the waterway regulation.